Submitted: 09 Mar 2022
Accepted: 31 May 2022
ePublished: 19 Jun 2022
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J Nephropharmacol. 2022;11(2): e10492.
doi: 10.34172/npj.2022.10492

Scopus ID: 85134150761
  Abstract View: 9303
  PDF Download: 2391


Effect of sertraline on intradialytic hypotension: a randomized controlled trial

Farahnaz Ghahremanfard 1 ORCID logo, Gholam Ali Mahdavi 1 ORCID logo, Majid Mirmohammadkhani 2 ORCID logo, Maliheh Yarmohammadi 1* ORCID logo

1 Department of Internal Medicine, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
2 Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran
*Corresponding Author: Corresponding author: Maliheh Yarmohamadi, Email: malihehyarmohamadi@yahoo.com, , Email: dr.yarmohamadi@semums.ac.ir


Introduction: Intradialytic hypotension is an important and common complication of hemodialysis. However, it seems that selective serotonin reuptake inhibitors (SSRIs) can manage patients’ blood pressure during hemodialysis.

Objectives: The present study aimed to investigate the effect of sertraline on intradialytic hypotension of the patients under hemodialysis.

Patients and Methods: The present randomized controlled trial included 18 patients under hemodialysis for end-stage renal disease (ESRD). The patients were randomly divided into the intervention and control groups. The intervention group received sertraline solely for intradialytic hypotension management, while the control group did not receive such intervention. The blood pressure assessments were conducted before, during, and after hemodialysis in both groups, then the data were analyzed.

Results: According to our results, the participants’ mean age was 63.72±9.91 years. The mean systolic and diastolic blood pressures were higher in the intervention group than in the control group before the hemodialysis. However, this difference was not significant for systolic blood pressure (P=0.279), while it was significant for diastolic blood pressure (P=0.02). Additionaly, no significant intergroup difference in systolic and diastolic blood pressure during and after hemodialysis was detected (P>0.05).

Conclusion: Sertraline had no significant effect on systolic and diastolic blood pressure during and after hemodialysis. However, it increased the mean systolic and diastolic blood pressure before hemodialysis which could prevent pre-dialytic hypotension without significant side effects. Therefore, it can be effective in preventing hypotension in patients under hemodialysis.

Trial Registration: The trial protocol has been approved by the Iranian Registry of Clinical Trial (identifier: IRCT2017080625732N23; https://en.irct.ir/trial/21499, ethical approval code; IR.SEMUMS.REC.1395.156).

Implication for health policy/practice/research/medical education:

Intradialytic hypotension is one of the most important and common complications of hemodialysis. In the present study, sertraline did not cause a significant change in the intradialytic and postdialytic blood pressure of the patients; however, it increased the mean systolic and diastolic blood pressure of the intervention group without any notable adverse effects. Therefore, sertraline can be used to prevent hypotension in patients under hemodialysis.

Please cite this paper as: Ghahremanfard F, Mahdavi GA, Mirmohammadkhani M, Yarmohammadi M. Effect of Sertraline on Intradialytic Hypotension: A Randomized Controlled Trial. J Nephropharmacol. 2022;11(2):e10492. DOI: 10.34172/npj.2021.10492

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